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Heavy metal poisoning refers to poisoning caused by heavy metal elements or their compounds with a relative atomic mass greater than 65, mainly including arsenic, chromium, cadmium, and lead poisoning, which is mainly caused by exposure to or eating a large amount of mining, smelting, industrial, and other sewage wastes or abandoned industrial products [4]

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PacBio sequencing kinetics allows for direct detection of base modifications, such as N6-methyladenine (m6A) and N4-methylcytosine (m4C)